GlyCare® LNFP-I/2’-FL
Highly abundant fucosylated HMO
GlyCare® LNFP-I/2’-FL (Lacto-N-Fucopentaose I/2’-Fucosyllactose)
LNFP-I/2’-FL (Lacto-N-Fucopentaose I/2’-Fucosyllactose) is a highly abundant, α1-2 fucosylated HMO in human milk. GlyCare® LNFP I is presently undergoing development.
Immunity and infections
Clinical studies suggest a relationship between HMOs and some immune outcomes in infants. Emerging science suggest that specific HMOs at the correct level of supplementation may help to reduce the risk of certain infections in infants consuming infant formula and in infants who are breastfed.
Emerging evidence from preclinical studies suggest that LNFP I may support immune health via inhibition of pathogen adherence to the intestinal cell wall1,2,3 and antimicrobial effects via binding to toxins4,5,1.
Gut health and microbiota
Clinical and preclinical studies report that HMOs may help to stimulate the growth of beneficial bacteria, which are believed to be important for development of the microbiota and gut health. Evidence from preclinical studies suggests LNFP I may have a role in gut health via its positive impact on growth of bifidobacteria which are considered to be beneficial in gut health6,7.
References
1. Crane, J. K., Azar, S. S., Stam, A., & Newburg, D. S. (1994). Oligosaccharides from Human Milk Block Binding and Activity of the Escherichia coli Heat-Stable Enterotoxin (STa) in T84 Intestinal Cells. The Journal of Nutrition, 124(12), 2358–2364. https://doi.org/10.1093/jn/124.12.2358
2. Lindenberg, S., Sundberg, K., Kimber, S. J., & Lundblad, A. (1988). The milk oligosaccharide, lacto-N-fucopentaose I, inhibits attachment of mouse blastocysts on endometrial monolayers. Journals of Reproduction & Fertility, 83.
3. Brassart, D., Woltz, A., Golliard, M., & Neeser, J. R. (1991). In vitro inhibition of adhesion of Candida albicans clinical isolates to human buccal epithelial cells by Fucα1→2Galβ-bearing complex carbohydrates. Infection and Immunity, 59(5), 1605–1613. https://doi.org/10.1128/iai.59.5.1605-1613.1991
4. El-Hawiet, A., Kitova, E. N., Kitov, P. I., Eugenio, L., Ng, K. K. S., Mulvey, G. L., … Klassen, J. S. (2011). Binding of Clostridium difficile toxins to human milk oligosaccharides. Glycobiology, 21(9), 1217–1227. https://doi.org/10.1093/glycob/cwr055
5. El-Hawiet, A., Kitova, E. N., & Klassen, J. S. (2015). Recognition of human milk oligosaccharides by bacterial exotoxins. Glycobiology, 25(8), 845–854. https://doi.org/10.1093/glycob/cwv025
6. Asakuma, S., Hatakeyama, E., Urashima, T., Yoshida, E., Katayama, T., Yamamoto, K., Kumagai, H., Ashida, H., Hirose, J., and Kitaoka, M. (2011). Physiology of consumption of human milk oligosaccha- rides by infant gut-associated bifidobacteria. Journal of Biological Chemistry, 286(40):34583–34592.
7. Zhao, C., Wu, Y., Yu, H., Shah, I. M., Li, Y., Zeng, J., Liu, B., Mills, D. A., and Chen, X. (2016). The one-pot multienzyme (OPME) synthesis of human blood group H antigens and a human milk oligosac- charide (HMOS) with highly active Thermosynechococcus elongatus α1-2- fucosyltransferase. Chemical Communications, 52(20):3899–3902.
HMO health benefits & solutions
Human milk oligosaccharides may support a number of health benefits such as immunity and gut health in early life.
Related articles
-
It takes guts and science: Unlock the latest research behind human milk oligosaccharides (HMOs) for human health
-
Supporting the infant microbiome: Exploring the science of synergistic synbiotics at ESPGHAN 2024
-
Explore the science behind synbiotic solutions combining HMOs and probiotics plus their benefits for infant health and development.
How can we help you?
-
New product concept
Got a notion for your next project or breakthrough innovation? Let’s put our heads together.
-
Sample request
Don’t just take our word for it. Discover how our solutions can support your product development journey.
-
-
Quick links
Customized blends of functional ingredients in one single, efficient premix.
Streamline your product development process and get to market faster.
Solutions to address consumers' health and lifestyle needs, giving you an edge in the market.
Talking Nutrition, Health & Care
Explore new science, consumer insights, industry news and more in our latest articles.
Discover educational whitepapers, webinars, publications and technical information.
Request samples, place orders and view product documentation.