Probiotic publications

Driving new research

Scientific research is key to our product offerings. We have over 20 years of experience in performing clinical trials and post-marketing studies, engaging in international, multidisciplinary collaborations across the globe to help build knowledge around our product concepts. Explore publications that support probiotics below.

The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial
Marijana Ranisavljev, Valdemar Stajer, Nikola Todorovic, Jelena Ostojic, Jelena Helena Cvejic, Robert E Steinert, Sergej M Ostojic
Eur J Nutr. 2024 Nov 26; 64(1): 28. doi: 10.1007/s00394-024-03546-0.

Efficacy and Safety of a Mixture of Microencapsulated Sodium Butyrate, Probiotics, and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome-A Randomized, Double-Blind, Placebo-Controlled Study.
Gąsiorowska A, Romanowski M, Walecka-Kapica E, Kaczka A, Chojnacki C, Padysz M, Siedlecka M, Banasik J, Sobolewska-Włodarczyk A, Wiśniewska-Jarosińska M, Bierła JB, Otaru N, Cukrowska B, Steinert RE
J Clin Med. 2024 Dec 24; 14(1): 6. doi: 10.3390/jcm14010006.PMID: 39797089 

Role of Lactobacillus rhamnosus (FloraActive™) 19070-2 and Lactobacillus reuteri (FloraActive™) 12246 in Infant Colic: A Randomized Dietary Study
S Gerasimov, J Gantzel, N Dementieva, O Schevchenko, O Tsitsura, N Guta, V Bobyk, V Kaprus
Nutrients, 2018 Dec 13;10(12): 1975

The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study
B Skrzydło-Radomańska, B Prozorow-Król, H Cichoż-Lach, E Majsiak, JB Bierła, W Kosikowski, M Szczerbiński, J Gantzel, B Cukrowska
Nutrients, 2020 Jul 5;12(7): 1999

Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy
Leanne K Mitchell, Helen S Heussler, Christopher J Burgess, Ateequr Rehman, Robert E Steinert, Peter S W Davies
J Autism Dev Disord, 2024 Oct 17. doi: 10.1007/s10803-024-06588-9

Effects of Microencapsulated Sodium Butyrate, Probiotics and Short Chain Fructooligosaccharides in Patients with Irritable Bowel Syndrome: A Study Protocol of a Randomized Double-Blind Placebo-Controlled Trial
Anita Gąsiorowska, Marek Romanowski, Ewa Walecka-Kapica, Aleksandra Kaczka, Cezary Chojnacki, Milena Padysz, Marta Siedlecka, Joanna B Bierła, Robert E Steinert, Bożena Cukrowska
J Clin Med, 2022 Nov 7;11(21): 6587

Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy
Leanne K Mitchell, Helen S Heussler, Christopher J Burgess, Ateequr Rehman, Robert E Steinert, Peter S W Davies
J Autism Dev Disord, 2024 Oct 17. doi: 10.1007/s10803-024-06588-9

Effect of probiotic Lactobacillus strains in children with atopic dermatitis
Vibeke Rosenfeldt, Eva Benfeldt, Susanne Dam Nielsen, Kim Fleischer Michaelsen, Dorthe Lisbeth Jeppesen, Niels Henrik Valerius, Anders Paerregaard
J Allergy Clin Immunol 2003 Feb; 111(2):389-95

Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis
Vibeke Rosenfeldt 1, Eva Benfeldt, Niels Henrik Valerius, Anders Paerregaard, Kim Fleischer Michaelsen
J Pediatr, 2004 Nov; 145(5):612-6

Effect of probiotic Lactobacillus strains on acute diarrhea in a cohort of nonhospitalized children attending day-care centers
Vibeke Rosenfeldt, Kim Fleischer Michaelsen, Mogens Jakobsen, Charlotte Nexmann Larsen, Peter Lange Møller, Michael Tvede, Heike Weyrehter, Niels Henrik Valerius, Anders Paerregaard
Pediatr Infect Dis J 2002 May; 21(5):417-9

Effect of probiotic Lactobacillus strains in young children hospitalized with acute diarrhea
Vibeke Rosenfeldt, Kim Fleischer Michaelsen, Mogens Jakobsen, Charlotte Nexmann Larsen, Peter Lange Møller, Pernille Pedersen, Michael Tvede, Heike Weyrehter, Niels Henrik Valerius, Anders Paerregaard
Pediatr Infect Dis J 2002 May; 21(5):411-6

Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells
P de Vos, Z Mujagic, BJ de Haan, R J Siezen, PA Bron, M Meijerink, JM Wells, AAM Masclee, MV Boekschoten, MM Faas, FJ Troost
Front Immunol, 2017 Aug; 23:8:1000

The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial
Z Mujagic, P de Vos, MV Boekschoten, C Govers, HJ H M Pieters, NJ W de Wit, PA Bron, AAM Masclee, FJ Troost 
Sci Rep, 2017 Jan 3:7:40128

Survival of Lactobacillus species (strain GG) in human gastrointestinal tract
B R Goldin , S L Gorbach, M Saxelin, S Barakat, L Gualtieri, S Salminen
Dig Dis Sci. 1992; 37(1):121-8

Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study
T Arvola , K Laiho, S Torkkeli, H Mykkänen, S Salminen, L Maunula, E Isolauri
Pediatrics 1999; 104(5):e64

Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children
J A Vanderhoof 1, D B Whitney, D L Antonson, T L Hanner, J V Lupo, R J Young
The Journal of Pediatrics 1999; 135(5):564-8

Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections
Iva Hojsak, Slaven Abdović, Hania Szajewska, Milan Milosević, Zeljko Krznarić, Sanja Kolacek
Pediatrics 2010; 125(5):e1171-7

A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children
E Isolauri, M Juntunen, T Rautanen, P Sillanaukee, T Koivula
Pediatrics 1991; 88(1):90-7

Efficacy of Lactobacillus GG as a diarrheal preventive in travelers
E Hilton, P Kolakowski, C Singer, M Smith
J Travel Med. 1997; 4(1):41-3

Probiotics reduce the prevalence of oral candida in the elderly - a randomized controlled trial
K Hatakka , A J Ahola, H Yli-Knuuttila, M Richardson, T Poussa, J H Meurman, R Korpela
J Dent Res. 2007; 86(2):125-30

Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial
Iva Hojsak, Natalija Snovak, Slaven Abdović, Hania Szajewska, Zrinjka Misak, Sanja Kolacek
Clin Nutr. 2010; 29(3):312-6

Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12® on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial
Dorte Eskesen, Lillian Jespersen , Birgit Michelsen , Peter J Whorwell , Stefan Müller-Lissner , Cathrine M Morberg
 Br J Nutr. 2015; 114(10):1638-46

Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents: A randomized, controlled trial
K H Pitkala , T E Strandberg, U H Finne Soveri, A C Ouwehand, T Poussa, S Salminen
J Nutr. Health Aging 2007; 11(4):305-11

Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study
Giuliano Rizzardini , Dorte Eskesen, Philip C Calder, Amedeo Capetti, Lillian Jespersen, Mario Clerici
Br J Nutr. 2012; 107(6):876-84

Probiotics in the management of atopic eczema
E Isolauri , T Arvola, Y Sütas, E Moilanen, S Salminen
Clin Exp Allergy 2000; 30(11):1604-10

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