Mitigate risk with ascorbic acid or alpha-tocopherol
Nitrosamines, found in various consumer products and pharmaceuticals, are recognized carcinogens linked to increased cancer risks. Recent discoveries of nitrosamines in commonly prescribed medications, such as valsartan and metformin, have resulted in significant recalls and disrupted patient care. This whitepaper examines the critical issue of nitrosamine contamination in pharmaceuticals and highlights innovative mitigation strategies. Learn how nitrite scavengers, including ascorbic acid and alpha-tocopherol, can serve as functional excipients to block harmful nitrosation reactions, ensuring safer drug formulations and compliance with evolving regulations.
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Ascorbic acid, and other nitrite scavengers, have been shown to act as functional excipients in drug products that can reduce nitrosamine formation by blocking nitrosation reactions.
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