Plasmin is an enzyme responsible for protein activation and degradation and is widely present in the epidermis of the skin. High Plasmin activities:

Affect the Cornified Envelope, important for the protection and maintenance of the skin barrier.

Activate MMP 9 leading to increased levels of inflammatory cytokines and red skin conditions. Increased levels of MMP 9, which are also elevated in sun-exposed skin, mediate degradation of type IV Collagen, a major component in the Dermal Epidermal Junction.

Activate MMP 1 levels leading to the degradation of type I Collagen so the skin has less structural support². When Collagen is compromised, skin loses elasticity & firmness.

Disbalanced bacteria: S. aureus affects skin barrier function via bacterial proteases, inflammation is triggered, and Plasmin is further activated leading to an even more vulnerable barrier¹.​

One biological target (Plasmin) to drive improvement across all skin layers.

SYN-UP® promotes healthy-looking skin by inhibiting Plasmin and Urokinase* activities and balancing key bacteria S. Aureus* and S. Epidermidis**..

SYN-UP® reduces skin sensitivity and redness by modulation of MMP 9, CXCL5 and IL-8 activities*.

SYN-UP® increases skin barrier functionality by up-regulation of Transglutaminase 1 (TGase1)*.

SYN-UP® helps to smooth and firm the skin by preventing the degradation of type IV Collagen* and by stimulating type I Collagen*.

_{*in vitro ​ **in vivo}