Proteins are involved in many physiological processes. Their broad acceptance as natural molecules, relatively high stability and well-defined actions have made them attractive for many skin-related indications, most notably in anti-aging therapy. Amongst them TGF-beta is a key protein, its proper activation is required for the synthesis of several highly relevant skin molecules such as Collagen and Glycosaminoglycans like HA. SYN®-HYCAN is a synthetic, patented tripeptide that mimics body’s own mechanism to transform latent TGF-beta to its active form. This particular activation leads to increased skin’s own synthesis of hyaluronan and stimulates the production of lumican and decorin, two important proteoglycans that are primarily responsible for maintaining a well-structured collagen matrix in the dermis.